No adverse developmental outcomes were observed in animal reproduction studies with administration of desmopressin during organogenesis to pregnant rats and rabbits at doses approximately less than 1 and 38 times, respectively, the maximum recommended human dose based on body surface area (mg/m2). Carbetapentane; Chlorpheniramine; Phenylephrine: (Moderate) Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Direct intravenous injectionNo dilution necessary.Inject IV over 1 minute. Treatment longer than 4 to 8 weeks has not been studied. The recommended dose for women is lower than for men because women are more sensitive to the effects of desmopressin sublingual tablet and had a higher risk of hyponatremia with the 55.3 mcg dose in clinical trials. On Days 1, 3 and 5, subjects were dosed intranasally with escalating doses of AV002 nasal spray. In certain clinical situations, it may be justified to try desmopressin in persons with factor VIII concentrations of 2% to 5%; however, carefully monitor these patients. Bioavailability was estimated using AUC(0-->t) for the oral and the intravenous periods. Her serum sodium concentration was 124 mmol/L within a day and was 135 mmol/L by the second day. Desmopressin has slight structural variations that reduce its affinity for V1 receptors and lessen its vasopressin activity and contractile action on visceral smooth muscle. Use in children requires careful fluid intake restrictions to prevent possible hyponatremia and water intoxication. Desmopressin has also been used in congenital or acquired bleeding disorders, including drug-induced platelet dysfunction (e.g., aspirin, dextran, ticlopidine, and heparin). Desmoperssin is the drug of choice for treatment of central diabetes insipidus and most commonly it is used as intranasal spray. Her serum sodium concentration was 124 mmol/L within a day and was 135 mmol/L by the second day. More than 50 kg: 150 mcg in each nostril. As her serum sodium concentration was 121 mmol/L, and her plasma osmolality was low in the presence of a high-normal urine osmolality and normal sodium excretion, she was treated with fluid restriction. Vasopressin, ADH: (Moderate) Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like vasopressin, ADH only with careful patient monitoring. Formoterol; Mometasone: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. Immune Checkpoint Inhibitors as a Threat to the Hypothalamus-Pituitary Axis: A Completed Puzzle. Diabetes Insipidus: < 12 years: No definitive dosing available. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Adjust morning and evening doses separately for an adequate diurnal rhythm of water turnover. Budesonide; Formoterol: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. Most adults require a maintenance dose of 20 mcg/day, administered as 10 mcg intranasally twice daily. Ddavp, Nocdurna, Octostim. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Lidocaine; Epinephrine: (Minor) The antidiuretic response to desmopressin may be reduced in patients receiving high doses of epinephrine concomitantly. Her serum sodium concentration was 124 mmol/L within a day and was 135 mmol/L by the second day. In the elderly, careful dosage selection and monitoring of renal function are recommended. Desmopressin is contraindicated in patients with known hypersensitivity to desmopressin or any ingredients in the preparation. Main menu. Fluticasone; Umeclidinium; Vilanterol: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. Dilute DDAVP Injection in sterile 0.9% Sodium Chloride Injection, USP and infuse slowly over 15 minutes to 30 minutes. The optimal dosage depends on the patient's response (duration of sleep and adequate, not excessive water turnover). Most patients respond to 1 to 2 doses; administer a second dose 8 to 24 hours after the first dose if needed. Children more than 12 years of age: The 0.83 mcg dose did not meet all prespecified efficacy endpoints in clinical trials, but may have a lower risk of hyponatremia. Methylprednisolone: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. The risk of toxic reactions (including water intoxication and low sodium concentrations) appears to be greater in the geriatric patient and other patients with impaired renal function. The distribution of the drug is unknown, and it is not clear whether desmopressin crosses the placenta. The pharmacokinetic profile of desmopressin is biexponential. The effect of DDAVP was measured on F VIII/vWF complex and on plasminogen activator release. Vincristine: (Major) Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with SIADH including vincristine. Trauma Surg Acute Care Open. In the elderly, careful dosage selection and monitoring of renal function are recommended. There is no information on the effects of desmopressin on the breast-fed infant or on milk production. Interrupt therapy for acute illness (e.g., systemic infection, fever, recurrent vomiting or diarrhea), extremely hot weather, vigorous exercise, or other conditions associated with increased water intake. A woman who took both desmopressin and ibuprofen was found in a comatose state. Factors associated with mortality of myxedema coma: report of eight cases and literature survey. Her serum sodium concentration was 124 mmol/L within a day and was 135 mmol/L by the second day. Ther Drug Monit. In contrast to vasopressin, desmopressin does not induce the release of adrenocorticotropic hormone or increase plasma cortisol concentrations. Use these drugs together with caution, and monitor patients for signs and symptoms of hyponatremia. As her serum sodium concentration was 121 mmol/L, and her plasma osmolality was low in the presence of a high-normal urine osmolality and normal sodium excretion, she was treated with fluid restriction. 150 mcg into each nostril once for a total dose of 300 mcg. In additio 50 kg or less: 150 mcg Copyright 1993-2021 Use combination with caution, and monitor patients for signs and symptoms of hyponatremia. Intranasal: 1 spray (1.5 mg/mL) in each nostril one time. %PDF-1.5 BJU Int. Chlorpromazine: (Major) Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs associated with water intoxication, hyponatremia, or SIADH including chlorpromazine. Doses may be titrated up to 0.6 mg PO once daily at bedtime, depending on individual patient response. Atenolol; Chlorthalidone: (Moderate) Monitor serum sodium more frequently during concomitant desmopressin and thiazide diuretic use due to increased risk of water intoxication with hyponatremia. Desmopressin can be started or resumed 3 days or 5 half-lives after the corticosteroid is discontinued, whichever is longer. Loop diuretics: (Contraindicated) Desmopressin is contraindicated with concomitant loop diuretic use due to an increased risk of hyponatremia. 2 0 obj Budesonide; Glycopyrrolate; Formoterol: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. %f2fDWBRex1*s GZhlNx;hI>l!dKc:cmEg2&M*?*q$|sa[`ov#1q=[`0GP/==g5>dof?N~;1Y Use combination with caution, and monitor patients for signs and symptoms of hyponatremia. The patient should close the open nostril with a finger from the empty hand and gently inhale while the nasal applicator is pumped 1 time. Use combination with caution, and monitor patients for signs and symptoms of hyponatremia. Her serum sodium concentration was 124 mmol/L within a day and was 135 mmol/L by the second day. After a 300 mcg intranasal dose of desmopressin levels of Factor VIII and vWF remain greater than 30 units/dL for 8 hours. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Fludrocortisone: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. Further hospitalization cost saving may be achieved through reduced The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Olmesartan; Amlodipine; Hydrochlorothiazide, HCTZ: (Moderate) Monitor serum sodium more frequently during concomitant desmopressin and thiazide diuretic use due to increased risk of water intoxication with hyponatremia. The usual dosage range is 0.1 mg to 1.2 mg PO per day, given in 2 to 3 divided doses. The recommended maintenance dose is 10 mcg/day to 40 mcg/day intranasally (0.1 mL/day to 0.4 mL/day) in 1 to 3 divided doses. Desmopressin should be avoided in women with preeclampsia and those with cardiovascular disease due to the fact that oxytocin and IV fluids are often used during labor and delivery, both of which increase the risk of desmopressin-induced hyponatremia. The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover. Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) Although the pressor activity of desmopressin is very low compared to its antidiuretic activity, large doses of desmopressin should be used with other pressor agents like phenylephrine only with careful patient monitoring. Consider risk vs. benefit as pregnant women with Hemophilia A or von Willebrand's disease as these patients may be at an increased risk for bleeding diatheses and hemorrhagic events at delivery; affected neonates may also be at risk of bleeding diatheses. new homes for sale edmonton north personal chef near los angeles, ca personal chef near los angeles, ca If used preoperatively, administer 2 hours before surgery. The woman had previously received desmopressin without the development of clinical symptoms of hyponatremia Prednisolone: (Major) Desmopressin is contraindicated with concomitant inhaled or systemic corticosteroid use due to an increased risk of hyponatremia. Repeat administration should be determined by laboratory response as well as the clinical condition of the patient. However, individualized dosing is recommended due to high inter-patient variability in response. Use combination with caution, and monitor patients for signs and symptoms of hyponatremia.
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