On October 1, 2014 the European Medicines Agencys Pharmacovigilance Risk Assessment Committee (PRAC) recommended that strontium ranelate (Protelos/Osseor, Servier) no longer be used to treat osteoporosis because of data demonstrating serious negative side effects. Krachler, M., Domej, W., and Irgolic, K. J. Skoryna SC. That means it may affect how strong your bones are. N.Engl.J.Med. So what is stable strontium exactly? In addition, strontium ranelate isstopped if a patient develops heart or circulatory problems during the course of treatment. View abstract. 1990;1(1):19-23. 2000;109(4):267-276. Study design: Prospective animal model study. N.Engl.J.Med. In 2013, the committee of the European Medicines Agency (similar to the FDA in the United States) recommended suspending strontium ranelate (brand name Protelos/Osseor) for treating osteoporosis. B., and Devogelaer, J. P. Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. This is the newest bone-building medication to treat osteoporosis. View abstract. (12). These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective. Groupe d'Etude de la Thrombose de Bretagne Occidentale. Radiother Oncol 1994;31:33-40. PROOF Study Group. Hahn, G. S. Strontium is a potent and selective inhibitor of sensory irritation. Initially Forteo was top contender (refrigeration requirement is an issue) until I came across Tymlos (refrigeration being easier to manage is one of several benefits over Forteo). Osteoporosis: Prevention With Calcium Treatment - Cleveland Clinic View abstract. View abstract. AlgaeCal Strontium Boost Reviews - Does This Product Really Work? Calcium is still the best mineral for bone health. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. JAMA 8-18-1999;282(7):637-645. 2014 Aug;53(8):1457-64. doi: 10.1093/rheumatology/keu018. 2007;357:nihpa40967. Incidence and mortality of venous thrombosis: a population-based study. Feeling slightly more pain in the areas of cancer in your bones for a few days. Vlad, S. C., LaValley, M. P., McAlindon, T. E., and Felson, D. T. Glucosamine for pain in osteoarthritis: why do trial results differ? My fear is the cost. 2007;18(12):1617-1624. Quintessence.Int. Ringe, J. D. and Doherty, J. G. Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. J Bone Miner Res 2001;16:299-308. . Strontium is a mineral found in seawater and soil. Modawal, A., Ferrer, M., Choi, H. K., and Castle, J. Apostolidis N, Paradellis T, Karydas A, et al. (24, 25). 2002;17(3):449-454. Gillam, D. G., Newman, H. N., Davies, E. H., and Bulman, J. S. Clinical efficacy of a low abrasive dentifrice for the relief of cervical dentinal hypersensitivity. Calcium Citrate. Magnesium Oxide: Benefits, Dosage, and Side Effects - Verywell Health Hwang, J. S., Chen, J. F., Yang, T. S., Wu, D. J., Tsai, K. S., Ho, C., Wu, C. H., Su, S. L., Wang, C. J., and Tu, S. T. The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. 5-3-2007;356(18):1809-1822. 1996;41(6):543-549. Ann Rheum Dis. 2008;39(4):321-325. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. It seems to play a role in how your body makes new bone while it slows the breakdown of old bone. Arch.Intern.Med. Get answers to some of the most common questions about osteoporosis treatment. After you stop taking any of these bone-building medications, you generally will need to take another osteoporosis drug to maintain the new bone growth. Low . Therapeutic Research Faculty 2020. All rights reserved. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. View abstract. Tofu, firm, made with calcium sulfate, cup 253 mg per serving. It was recommended to my sister by her doctor. I did find some information on the Mayo Clinic website on osteoporosis. Its a fancy word for the development of cavities! Ananthraman, J. and Shahani, S. N. Clinical management of dentin hypersensitivity using cathode and anode iontophoresis. Sr can be found in Group 2 of the periodic table. View abstract. J.Bone Miner.Res. (2). Available at: https://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. 4-12-2005;172(8):1039-1043. 2005 - 2023 WebMD LLC. Please note the date of the last review on all articles. 2013 Feb;72(2):179-86. doi: 10.1136/annrheumdis-2012-202231. When people are looking into options for osteoporosis medications, some people want to take the natural route and choose to make strontium a part of their treatment plan. Calcif Tissue Int 2001;69:121-9. . Use strontium supplements with caution if you have kidney disease. It is given as an injection every month at your doctor's office and is limited to one year of treatment. View abstract. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? 1980;51(10):578-581. 2010;21(2):42-48. A meta-analysis of randomized controlled trials. Boron is an element. Human biokinetics of strontium--part II: Final data evaluation of intestinal absorption and urinary excretion of strontium in human subjects after stable tracer administration. [3] Bartl, R. & Bartl, C.The Osteoporosis Manual: Prevention. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. Both soil and seawater contain this mineral. Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate. (3). View abstract. Hollriegl, V., Li, W. B., and Oeh, U. Effects of strontium ranelate on spinal osteoarthritis progression. Cochrane.Database.Syst.Rev. If side effects are persistent or worsen, it is best to talk to your healthcare provider. (21). It boils at 2,520 degrees F (1,382 degrees C) and melts at1,431 degrees F (777 degrees C). Further studies are warranted to determine which radiopharmaceutical is preferred for pain relief and/or improvement of survival. 2003;14 Suppl 3:S56-S65. Obtaining strontium from your diet by eating seafood, whole grains,beans, spinach, lettuce, celery, androot vegetableslike carrots and potatoes is the safest way to boost your strontium levels. Calcif Tissue Int 2000;67:122-7. Wang, C. T., Lin, J., Chang, C. J., Lin, Y. T., and Hou, S. M. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9. View abstract. The treatment can sometimes cause anemia after a few weeks, so you need to have regular blood tests after the treatment. View abstract. Because strontium atoms are heavier than calcium atoms, swapping some of the calcium atoms with strontium atoms will make the bone mineral density appear to increase. Busse, B., Jobke, B., Hahn, M., Priemel, M., Niecke, M., Seitz, S., Zustin, J., Semler, J., and Amling, M. Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure. Some years later in 1808, it was was isolated in its metallic formusing electrolysisby Sir Humphry Davy at the Royal Institution in London. If youre not into chemistry, then those scientific facts probably dont mean that much to you. Bone 2006;38(2 Suppl 1):23-27. To avoid this interaction, take antacids at least two hours after taking strontium products. Toxicity is minimal and consists of a transient 30 percent reduction of the [platelet] count. Rizzoli R, Chapurlat RD, Laroche JM, et al. Reginster, J. Y. Kidney Int 2000;58:981-8. J.Periodontol. Sairanen S, Karkkainen M, Tahtela R, et al. Fluoride helps protect your teeth from the acid that is released when this happens. Strontium can attach to some antibiotics called tetracyclines in the stomach. Increased serum strontium levels in dialysis patients: an epidemiological survey. With a few simple measures, the application of Sr-89 causes no problems. Theres not enough research to know if strontium fights osteoporosis. Middleton ET, Steel SA, Aye M, Doherty SM. Eur.J.Nucl.Med. According to the Michigan Health website: Compared with children with fewer cavities, enamel samples from children with high numbers of caries have been found to contain significantly less strontium. Osteoporos.Int. Connect with thousands of patients and caregivers for support and answers. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019, As a service to our readers, American Bone Health provides access to our library of archived content. J.Bone Miner.Res. 1999;25(9):689-694. A typical dosage of strontium in over-the-counter supplements is 680 mg a day. 2003. To avoid this interaction, take strontium at least 2 hours before or after taking tetracyclines. 2009;41(7):559-562. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Strontium is a mineral and alkaline earth metal like calcium, and it seems to work similarly to calcium in the body with its main benefit being a boost to bone health. View abstract. Kidney Int 2003;64:534-43. . All Rights Reserved. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. 1998-2023 Mayo Foundation for Medical Education and Research. View abstract. A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. You may not realize it, but its possible that you have used, or are currently using, a toothpaste the contains strontium. 2005 - 2023 WebMD LLC. Can Strontium Boost Bone Health And Prevent Osteoporosis? Osteoporos.Int. ", UC Davis School of Medicine: "Strontium Citrate for Osteoporosis Prevention Evaluation (SCOPE). Calcium and calcium supplements: Achieving the right balance Strontium is similar to calcium. Complete your request online or contact us by phone. 2000;57(3):1107-1114. @kishanvasekar My girlfriend has osteoporosis and the Dr put her on high doses of Vit D-3 sunshine exercise especially weights ,swimming .She is doing good. View abstract. Posted: 09/28/19;Revised: 09/25/20. Strontium is considered to be safe in normal food amounts and as a toothpaste ingredient. 2006;54(11):3494-3507. Strontium Citrate is one of the most common types of Strontium used in the dietary supplement field for bone health. McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., Meunier, P. J., and Reginster, J. Y. Acta Biomater. Rheumatol.Int. 2016 Jan;27(1):211-8. doi: 10.1007/s00198-015-3266-z. [Efficacy and safety of bivalos therapy for postmenopausal osteoporosis. View abstract. 7-27-1965;162(989):458-472. Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., and Browne, M. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. View abstract. View abstract. Robinson, R. G., Spicer, J. 1992;19(10):737-740. Efficacy and safety of strontium ranelate in the treatment of osteoporosis in men. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Taking strontium with tetracyclines can decrease their effects. Any feedback to help me through this maze will be highly appreciated. 2006;21(4):536-542. Immune function. Overview. [4] Simpson, Lani. J.Clin.Periodontol. Strontium is a trace mineral that may help keep bones strong by preventing bone loss and promoting bone growth. A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. (10), Radioactive strontium-89 is given intravenously for advanced bone cancer or cancer that has spread to the bones such as metastatic prostrate cancer. Cochrane Database Syst Rev 2006;(4):CD005326. View abstract. J.Clin.Endocrinol.Metab 2010;95(3):1174-1181. (23), In general, taking very high doses of a Sr supplement is typically not considered safe and taking too much could even damage bones, so be careful when taking strontium, as recommended by the ATSDR (Agency for Toxic Substances and Disease Registry). A double-blind, randomized placebo-controlled trial published in The Journal of Clinical Endocrinology and Metabolism looked at the effects of Sr on 261 men with primary osteoporosis. 5-10-2001;344(19):1434-1441. Selective Estrogen Receptor Modulators (SERMs), Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Bone Mineral Density Test: What to Expect, Newer Osteoporosis Treatments Build Stronger Bones, Breakfasts for Strong Bones: 12 Foods to Boost Bone Health, Cant move very much, either for a short time, such as after surgery, or for the long term, such as because of a disability. Basically, it is like you are consuming rocks. Periodontics. How can Sr be used? Arthritis Res.Ther. Most people who take strontium citrate report their fractures STOP. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Research shows that a special prescription form of strontium (strontium-89 chloride) given intravenously (by IV) reduces pain from metastatic, Weak and brittle bones (osteoporosis). Brand: Algaecal. Effect of risedronate on the risk of hip fracture in elderly women. Select a condition to view a list of vitamins. Reichenbach, S., Blank, S., Rutjes, A. W., Shang, A., King, E. A., Dieppe, P. A., Juni, P., and Trelle, S. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Estrogens might decrease how fast the body gets rid of strontium. About 99% of the strontium in the human body is concentrated in the bones. If youre suffering from bone or prostate cancer, radioactive strontium therapyshould only be given by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. 2006;55(8):669-675. Bruyere, O., Roux, C., Detilleux, J., Slosman, D. O., Spector, T. D., Fardellone, P., Brixen, K., Devogelaer, J. P., Diaz-Curiel, M., Albanese, C., Kaufman, J. M., Pors-Nielsen, S., and Reginster, J. Y. Reginster, J., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., and Eastell, R. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. I. Inhibition of intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis. J Endod 2002;28:34-5. Marquis, P., Roux, C., de la Loge, C., Diaz-Curiel, M., Cormier, C., Isaia, G., Badurski, J., Wark, J., and Meunier, P. J. Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis. View abstract. 1984;55(12):720-725. Acta Derm Venereol. Moise H, Chettle DR, Pejovic-Milic A. Seeman, E., Devogelaer, J. P., Lorenc, R., Spector, T., Brixen, K., Balogh, A., Stucki, G., and Reginster, J. Y. Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. How Well are You Living With Ankylosing Spondylitis? 2006;(2):CD005321. Description Pure Encapsulations' Strontium capsules provide one of the many trace minerals essential to bone health. The effect of a strontiumhloridetoothpaste on root hypersensitivity in a controlled clinical study. View abstract. Rizzoli, R., Laroche, M., Krieg, M. A., Frieling, I., Thomas, T., Delmas, P., and Felsenberg, D. Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Cheung, K. M., Lu, W. W., Luk, K. D., Wong, C. T., Chan, D., Shen, J. X., Qiu, G. X., Zheng, Z. M., Li, C. H., Liu, S. L., Chan, W. K., and Leong, J. C. Vertebroplasty by use of a strontium-containing bioactive bone cement. 2012. My teeth are really strong and it feels like my bones are too. 2006;54(10):3205-3211. 2010;46(4):1038-1042. doi: 10.1016/j.bone.2009.12.006. Arch.Intern.Med. (1) A radioactive form is even used as a form of cancer treatment for bone cancers andprostate cancer. Metastron prescribing information. JAMA 12-23-1998;280(24):2077-2082. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. Osteoporos.Int. View abstract. Strontium Demystified: Everything You Wanted To Know Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD.